MICRONEEDLE
PATCH
TIMELINE
​
2015
40 YEARS IN THE MAKING
1990
First patent for a patch - described as a transdermal drug patch with “microtubes” - used a combination of conductors and electrodes to deliver medications via tiny electrical output by Dan Sibalis, an employee of Drug Delivery Systems Inc.
The video above details the collaboration between Emory University School of Medicine and Georgia Tech. and how they worked together to produce an effective patch.
Chris Edens and Marcus L. Collins at Georgia Tech and Emory University develop of the patch to vaccinate individuals against measles. The patch is developed to penetrate the dermal layer of the skin to painlessly dispense vaccinations.
Development a glucose-responsive insulin microneedle patch. Designing the needles to contain hypoxia-sensitive hyaluronic acid-based vesicles enabled quick release of insulin when in a hyperglycemic state. This “smart insulin patch” is developed to with glucose-responsive mechanisms which can regulate the blood glucose levels.
2017
VAXXAS, a drug delivery company, further developed Mark Kendall's nano patch and begun clinical trials on the patch for vaccine applications. They hope to run trials in to determine the effectiveness of a polio vaccine.
1995
Robert O Ginaven and Daniel Faccioti register the first patent that investigated the use of microneedles to penetrate the top layer of the skin for a drug-release system.
First solid microneedles to increase skin permeability created.
Inventors Joachim Eicher and Bernd Zierenberg register the first patent that investigated the use of microneedles to penetrate the top layer of the skin for a drug-release system.
1999
Mark R. Prausnitz, Mark G. Allen, and Inder-Jeet Gujral of the Georgia Tech Research Corportation first implement a reservoir in the microneedle patch to store the drug/medication.
2001
Vadim Vladimirovich Yuzhakov, Faiz Feisal Sherman, Grover David Owens, Vladimir Gartstein of The Procter and Gamble Company first develop of a “smart” microneedle patch that has sensors to track body fluids while delivering medication/drugs.
2010
Patch products currently available in the USA for the transdermal treatment of local tissue sites. These products are mainly indicated for the treatment of pain associated with arthritis, neuropathy, and muscle sprain and strain. One FDA-approved lidocaine/tetracaine product for local anesthesia (Synera®) utilizes CHADD® technology was also developed.
Mark Kendall at the University of Oxford engineers a microneedle patch that targets cells for the vaccination of DNA itself
2006
1979
A patch was created to cure motion sickness through delivery of drugs through the skin by Charles D. Wood
Derek T. O Hagan at the Unviersity of Nottingham first produces biodegradable microparticles that are used with mice when investigating the drug delivery of ovalbulmin (that was entrapped in the microparticles).
1993
The video above details Oxford's developments with their microneedle patch. They additionally discuss the future steps necessary to release the patch to the public.
2003
Jung-Hwan Park, Mark G. Allen, and Mark R.Prausnitz of Georgia Tech and Emory University develop a biodegradable polymer microneedle patch that can dissolve once drug delivery is done.
Microneedle patches aimed toward treating Alzheimer's patients was developed. Hydrogel needles were formulated to dissolve with a donepezil hydrochloride formed from poly(vinylpyrrolidone) or poly (methyl vinyl ether co-maleic anhydride/acid) (Gantrez®) polymers, into the skin. This actively prevents acetylcholine breakdown in brain tissue.